What is Polydeoxyribonucleotide (PDRN) and Why is it So Popular?
If you have been researching ways to regenerate your skin online, Rejuran PDRN treatment might have come up. It has gained prominence for promising patients great results.
PDRN is a naturally-occurring protein which has been scientifically demonstrated to possess many clinical applications, including anti-inflammatory, anti-apoptotic, bone regenerative, and skin priming properties.
What is PDRN?
Polydeoxyribonucleotide (PDRN) is an naturally-occurring building block of DNA that stimulates your skin cells to regenerate collagen, otherwise known as cellular regeneration, to reverse signs of aging and scarring through skin repair. Miracle skin injections or Ying Er Zhen injections, otherwise known as PDRN skin treatments are used to reduce fine lines and wrinkles as well as improve texture and hydration of your skin.
PDRN is extracted from salmonid enzymes and goes through an intensive sterilization and purification process to ensure its purity and free of peptides or proteins. With a molecular weight between 50-1500kDa and biological activity similar to adenosine (it binds to its A2A receptor and induces relaxation) this medication stands out among others A2A agonists such as dipyridamole, regadenoson, or defibrotide - something unique about PDRN!
Animal studies have demonstrated the efficacy of PDRN as a wound healing aid and tissue regeneration stimulant by stimulating cell proliferation. Furthermore, this therapy was found to inhibit pro-inflammatory cytokine production such as IL-1, IL-6 and TNF-a while simultaneously increasing anti-inflammatory production such as IL-10; furthermore it can inhibit excess fibrosis accumulation as well as neointimal hyperplasia accumulation.
PDRN injections have proven successful at relieving patients of elbow tendinosis by injecting it directly into affected tendons. Studies have demonstrated that PDRN relieves pain and restores range of motion by inhibiting excessive fibrosis production which leads to tendon damage. US-guided needle injections use 27 gauge needles with minimal risk. Treatment has been well received by patients without reported adverse side effects.
PDRN has long been used as an anti-aging agent due to its ability to strengthen skin barrier function, reduce fine lines and wrinkles, restore elasticity, heal scars, minimize pores and acnes as well as reduce dark spots for overall whitening of complexion. Furthermore, studies have demonstrated its ability to accelerate tissue repair processes at a cellular level as well as protect the skin from UV damage.
PDRN stands out from many other treatments by being non-invasive and needing no downtime. It works by stimulating collagen and elastin production - essential components of youthful, healthy skin - through increasing the blood vessel permeability to allow more oxygen into cells to stimulate tissue regeneration. Furthermore, studies have also demonstrated its effect on angiogenesis as well as bone formation.
PDRN can be administered via injection; however, its efficacy has also been demonstrated with creams and topical applications. Extracted from salmon fish (Oncorhynchus mykiss or Oncorhynchus keta), its DNA is extracted and purified after separation by chromatin digestion to remove contaminants before being diluted for injection into skin for its desired effects.
Studies conducted using an experimental ischemic skin flap model have demonstrated that PDRN can significantly enhance skin healing processes and vascularization, particularly in areas of poor blood flow. More specifically, it led to a significant increase in VEGF-driven angiogenesis that resulted in faster flap closure rates.
Studies have also reported that classic PDRN can promote wound healing via multiple mechanisms, including increasing cell migration to attempt closure of wound sites in human fibroblasts. This effect can be linked to activating JNK which causes increased expression and activity of several growth factors and cytokines involved with wound repair.
Studies have also demonstrated the efficacy of PDRN treatments in areas with limited angiogenesis, such as diabetic ulcers. Furthermore, studies have also proven its ability to promote tissue regeneration - thus aiding healing and preventing scarring.
Polydeoxyribonucleotides have quickly become one of the hottest new skin regenerating treatments. These potency natural compounds have proven their efficacy as creams and serums to dramatically enhance skin health and beauty, especially where wound healing is impaired, such as diabetic foot ulcers or burn scars. Furthermore, PDRNs have also proven beneficial as hair regenerative therapy or an anti-age serum.
PDRN is an active deoxyribonucleotides mixture with molecular weights ranging from 50-1500kDa that is extracted and purified from Salmon trout (Oncorhynchus mykiss) or Chum salmon (Oncorhynchus keta) sperm cells for purification and then administered directly into human subjects in preclinical studies, where its activity has been demonstrated in preclinical studies to include tissue repairing, anti-ischemic, and anti-inflammatory activities. In particular PDRN stimulates proliferative cells while increasing collagen synthesis in skin. Furthermore, binding to A2A receptors allows binding with proinflammatory cytokines while stimulating production of anti-inflammatory cytokines allows its use leading to decreased inflammation and increased collagen synthesis; further reduction of inflammation apoptosis leads to reduction of inflammation apoptosis of skin.
An experimental ischemic skin flap model demonstrated that PDRN increased blood flow as measured by laser Doppler and promoted strong VEGF-driven angiogenesis, improving survival rates of skin flaps while decreasing hard-to-heal diabetic foot ulcers formation. Furthermore, clinical trial using topical PDRN cream on patients' feet demonstrated nearly doubled rates of complete healing for chronic diabetic foot ulcers!
These results have led to a new generation of cosmeceutical products containing PDRN, providing visible lifting effects, improving skin elasticity, and maintaining moisture balance in the skin. PDRN serum can easily be used at home without downtime or needles - its popularity has spread from Korean clinics worldwide, with its high concentration of PDRN providing optimal results.
PDRN treatments can be highly beneficial to individuals suffering from various skin issues, including slow healing scars, dark spots or lesions on the face and post-acne hyperpigmentation. Studies have proven its ability to reverse these conditions by stimulating cell regeneration and collagen production as well as improving skin elasticity, firmness and decreasing fine lines and wrinkles. Furthermore, various methods exist for administering PDRN into the skin to promote healing and boost collagen production.
Classic PDRN can have many beneficial cellular effects, one being its pleotropic effects on wound healing. A2A receptor stimulation has been demonstrated to decrease pro-inflammatory cytokines such as Tumor Necrosis Factor-a from being released and released again into circulation.
Classic PDRN therapy can also induce nitric oxide formation and angiogenesis in wound tissue, leading to improved blood flow and vessel formation - this is particularly vital in diabetic foot ulcers where reduced circulation and poor vascularity may worsen over time.
Studies have demonstrated that PDRN can significantly enhance wound closure quality in mice by decreasing lipid accumulation and speeding tissue repair, stimulating proliferation of fibroblast cells that produce collagen production, as well as stimulating their proliferation to produce new tissues - and all without producing side effects!
PDRN can not only aid wound recovery but can also be utilized in other regenerative applications. At present, the FDA has approved its use in treating burns, chronic wounds and diabetic foot ulcers; as well as effectively reversing atrophic scarring and increasing dermis thickness.
There are various methods of administering PDRN treatments, with injection being the most popular route. These injections contain complex molecules capable of increasing cell growth in the body and therefore stimulating skin regeneration.