Polydeoxyribonucleotide (PDRN) is a DNA-derived drug that has been used to aid skin regeneration and wound healing in many different conditions. It is composed of deoxyribonucleotide polymers where 50 to 2000 base pairs are combined in a chain.

PDRN has been shown to increase cell growth in vitro, which is why it is often utilised as a skin regenerator. It can also be effective in certain conditions where wound healing is impaired, such as diabetes and severe burns.

Skin Regeneration

PDRN is an effective skin injectable that stimulates tissue repair, reduces inflammation and promotes new cell growth. Unlike collagen or HA, PDRN works to improve the appearance of fine lines and wrinkles as well as scarring, without breaking the skin barrier.

PDRN has excellent biocompatibility with human skin, making it safe for most subjects to use. It’s also effective at reducing redness, sensitivity, sun-damaged skin, age spots and uneven skin tone.

In addition, PDRN increases the production of collagen and elastin. This results in firmer and younger-looking skin.

Skin regeneration is vital for preventing the signs of aging. PDRN can also be used to speed up the process of wound healing. This makes it an effective treatment for diabetic foot ulcers, burns and scars.

Wound Healing

Wounds that don't heal within 3 months are a common problem that affects 2% of the population and cost over $3 billion per year to treat. Rapid wound healing can help to reduce the length of hospital stay and improve rehabilitation outcomes.

PDRN (Placentex Integro, Mastelli Srl-Sanremo, Italy) is an A2 purinergic receptor agonist that stimulates cell proliferation and promotes neogenesis. It is a deoxyribonucleotide linear polymer, which has been shown to enhance the cell cycle and the repair process in various cell types including fibroblasts, macrophages, and vascular endothelial cells.

PDRN has been used in clinical trials to accelerate tissue regeneration and to promote neogenesis. It has been proven to be a useful treatment for orthopaedic conditions such as plantar fasciitis and chronic tendinosis with improved wound healing, skin oedema and reduced pain.


PDRN is an anti-inflammatory compound that can be used to fight chronic inflammation and improve skin healing. It has been proven to promote the growth of new skin tissue and decrease inflammation.

Moreover, PDRN is also an anti-aging agent that can prevent the premature aging of the skin. It can help to reverse the effects of oxidative stress, which can contribute to premature aging of the skin by triggering ROS production, leading to an increase in inflammatory cytokines.

It also boosts the immune system to fight inflammation. In addition, PDRN can promote the development of collagen and the formation of new blood vessels to repair damaged skin.

In pre-clinical studies, PDRN has been shown to accelerate the healing process in diabetic wounds (Galeano et al., 2008). It has been found to stimulate the growth of fibroblasts and enhance angiogenesis, thereby improving skin healing.


PDRN is a powerful anti-aging treatment that works to promote skin regeneration and boost wound healing. It can be used to reverse the signs of aging and scars by boosting the metabolic activity of cells in your skin that regenerate collagen.

It also has a number of other benefits such as the ability to reduce pigmentation spots and dark circles on your face. This means that it can be a great treatment to use for patients who have experienced post-acne hyperpigmentation and other early-onset aging signs.

PDRN is a versatile ingredient that can be used as an adjunct to many aesthetic therapies, but it has particular advantages when it is combined with specific laser treatments. This is especially the case with PDRN Perfection, which can be used in synergy with Lustrous Skin or Dazzling Skin programs by adding it to their topical treatments. This enables favourable penetration of the ingredients after the laser treatments.

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